up to 40 units can be connected to the same PC via a USB hub. A Forced Swim specific mode of ANY-maze (60000-FST), also included in the full license, collects the information from the electronics, automatically scores number of rotations and performs statistical analysis. The device connects to the PC via a USB cable provided as standard. The FST 40803 includes rotation encoder & temperature sensor. During the test proper: mice turn the wheel vigorously and when they give up attempts to escape from the water, the wheel stops revolving and the number of rotations are recorded.
In the habituation phase, the rodent is left for 5 minutes to explore the tank, and will identify the wheel as a possible escape way. Automating the open field test with ANY-maze is straightforward and provides results that would be difficult, if not impossible, to determine. this water wheel test is more appropriate as screening test for antidepressants than Porsolt’s test with regard to both objectivity and specificity.” (Nomura et al.) The open field test is about emotionality and locomotion, so automating it requires adaptable zone design and a comprehensive selection of locomotor related results. In fact, automatically scored wheel rotations directly correspond to active escape attempts. Antidepressant effects of focused ultrasound induced blood-brain-barrier. The forced swimming test (FS) is commonly used. Assessment of depression-like behavior and anhedonia after repeated cycles of binge-like ethanol drinking in male C57BL/6J mice. General locomotor activity was assessed using the open field apparatus and recorded using ANY-maze software. Nomura et alia in their paper of 1982 introduces an objective measurement, the number of rotations, as it involves a small water wheel set in a water tank, overcoming the bias intrinsic to Porsolt’s method. Sex differences in behavioral and neurochemical effects of gonadectomy and aromatase inhibition in rats. Automatically scored wheel rotations directly correspond to active escape attempts.Īlthough the Porsolt Forced Swim Test remains one of the most widely used behavioral test for screening antidepressants, the modification suggested by S.